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  • Trimethylchlorosilane (TMCS)  CAS :75-77-4

    Trimethylchlorosilane (TMCS) CAS :75-77-4

    Name: Chlorotrimethylsilane CAS number: 75-77-4 Molecular formula: C3H9ClSi Molecular weight: 108.64 EINECS number: 200-900-5 Mol file: 75-77-4.mol

  • Trimethylethoxysilane CAS :1825-62-3

    Trimethylethoxysilane CAS :1825-62-3

    Name: Ethoxytrimethylsilane CAS number: 1825-62-3 Molecular formula: C5H14OSi Molecular weight: 118.25 EINECS number: 217-370-6 Mol file: 1825-62-3.mol

  • Dimethyldimethoxysilane CAS1112-39-6 DMDMS

    Dimethyldimethoxysilane CAS1112-39-6 DMDMS

    Specification English name: Dimethyldimethoxysilane CAS number: 1112-39-6 Molecular formula: C4H12O2Si Molecular weight: 120.22 EINECS number: 214 189 4 Mol file: 1112-39-6.mol Applications As a structural control agent, chain extender, and filler treatment agent, it is widely used in the treatment of organic silica gel and white carbon black Purpose As a structural control agent, chain extender, and filler treatment agent, it is widely used in the treatment of organic silica gel and white carbon black. This product is used as a structural control agent and chain extender to improve mechanical processing performance, extend the storage time of rubber blends, and can replace hydroxyl silicone oil for use. Widely used in the treatment of organic silicone and white carbon black Purpose Dimethyldimethoxysilane is used as a structural control agent and chain extender to improve mechanical processing performance, extend the storage time of rubber blends, and can replace hydroxy silicone oil....

  • Iodotrimethylsilane CAS:16029-98-4 (TMIS)

    Iodotrimethylsilane CAS:16029-98-4 (TMIS)

    Properties of trimethyliodosilane Melting point<0 ° C Boiling point 106 ° C (lit.) Density 1.406 g/mL at 25 ° C (lit.) Refractive index n20/D 1.471 (lit.) Flash point − 25 ° F Storage conditions -20 ° C Solubility Reacts Form Liquid Specific gravity 1.47 Clear colors to reddish Water solubility reactions Sensitivity: Moisture&Light Sensitivity Hydrolysis sensitivity 8: Reacts quickly with moisture, water, protoc solvents BRN 1731136 Stability Sensitivity (Reactive) InchiKey CSRZQMIRAZTJOY-UHFFFFAOYSA-N CAS Database 16029-98-4 (CAS DataBase Reference) NIST Chemical Information Iodotrimethylsilane (16029-98-4) EPA Chemical Information Silane, iodotrimethyl - (16029-98-4)

  • Hexamethyldisilane CAS:1450-14-2 (HMD)

    Hexamethyldisilane CAS:1450-14-2 (HMD)

    Properties of Hexamethyldisilane Melting point 9-12 ° C (lit.) Boiling point 112-114 ° C (lit.) Density 0.715 g/mL at 25 ° C (lit.) Refractive index n20/D 1.422 (lit.) Flash point 29 ° F Storage conditions Store at<=20 ° C Sol common organic solvents; Insul H2O Form liquid Specific gravity 0.729 Colorless Insoluble in water Double in alcohol, ether and acetone Hydrolysis sensitivity 1: no significant reaction with acute systems BRN 1633463 Stability InchiKey NEXSMEBSBIABKL-UHFFFAOYSA-N CAS Database 1450-14-2 (CAS DataBase Reference) NIST Chemical Substance Information Disilane, hexagonal - (1450-14-2) EPA Chemical Substance Information Disilane, hexagonal - (1450-14-2)

  • Hexamethyldisiloxane CAS:107-46-0

    Hexamethyldisiloxane CAS:107-46-0

    Introduction:  Hexamethyldisiloxane (silicone ether, MM sealing agent) is a colorless and transparent liquid that is prone to deliquescence. Insoluble in water, soluble in various organic solvents. Used as silicone oil, silicone rubber, pharmaceuticals, gas chromatography stationary liquids, analytical reagents, hydrophobic agents, etc. Obtained by hydrolysis of trimethylchlorosilane.  The physical properties of hexamethyldisiloxane  colorless and transparent liquids. Easily deliquescent, flammable, and in contact with high heat, open flames, and strong oxidizing agents, there is a risk of combustion. Boiling point 99.5 ℃. Flash point -1.1 ℃. Relative density (d2525) 0.7606. The refractive index is 1.3750. Insoluble in water, soluble in various organic solvents.  Hexamethyldisiloxane is an important primary organic silicon raw material, often used as a capping agent in the production of silicone oil, or as a cleaning agent for silicone rubber, pharmaceuticals, gas c...

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Anhui Techchem Industrial Co.,Ltd. will participate in the Shanghai CPHI China 2026 exhibition.

Anhui Techchem Industrial Co.,Ltd. will participate in the Shanghai CPHI China 2026 exhibition.

Anhui Techchem Industrial Co.,Ltd. will participate in the Shanghai CPHI China 2026 exhibition. The 24th CPHI China 2026 will grandly kick off at the Shanghai New International Expo Center from June 1...

The Physiological Function of Vitamin B1
2023-07-18
Vitamin B1, also known as thiamine, is one of the earliest vitamins discovered by humans. In 1926, it was successfully isolated, and in 1936, vitamin B1 was artificially synthesized and its structure was announced. The molecule of vitamin B1 is formed by connecting one midine ring and one thiazole ring through a methylene bridge. Vitamin B1 has a slight yeast odor and is easily soluble in water, slightly soluble in ethanol. Stable in both dry and acidic solutions in the form of hydrochloride and nitrate; Accelerated decomposition and destruction in alkaline environments, especially during heating. Vitamin B1 is extremely sensitive to Sulfite. In the presence of Sulfite, it quickly decomposes into pyrimidine and thiazole, and loses its activity.

Some food ingredients contain anti vitamin B1 factor, such as fish intestinal cavity and Pteridophyte vitamin B1 enzyme, which can break vitamin B1 molecule by Single displacement reaction with methylene through amino or mercapto compounds. In addition, some vegetables, fruits, such as red cabbage, black currant, tea and coffee contain polyhydroxyphenols, which can inactivate vitamin B1 through Redox. Long term consumption of such foods in large quantities may lead to vitamin B1 deficiency.

Absorption, Transport, and Metabolism
Vitamin B1 is mainly absorbed in the jejunum at low concentrations μ At mol/L, it mainly relies on the active transport system mediated by the carrier, and the absorption process requires the presence of Na+and the consumption of ATP. At high concentrations, it can be absorbed by passive diffusion, but the efficiency is very low. One oral dose of 2.5-5.0mg, most of which cannot be absorbed. After absorption, vitamin B1 is converted into pyrophosphate in the cells of jejunum mucosa through phosphorylation, and the blood is mainly transported by red blood cells in the form of pyrophosphate. Vitamin B1 exists in various tissues and cells in different forms. Taking brain tissue as an example, thiamine pyrophosphate (TPP) accounts for 79%, thiocolloid monophosphate (TMP) accounts for 11%, and thiamine triphosphate (TTP) and free vitamin B1 account for about 5% respectively. The distribution in other tissues is similar to that in brain tissue.
The total amount of vitamin B1 in adults is approximately 30mg. The content levels in various tissues and organs vary, with the liver, kidney, and heart being the highest, 2-3 times higher than the concentration in the brain. The Biological half-life of vitamin B1 in vivo is 9.5~18.5 days, and its metabolites are pyrimidine, thiazole and their derivatives. Metabolic experiments using 14C labeled vitamin B1 have found that 22 of the decomposition products in urine come from pyrimidine and 29 from thiazole.

Physiological function
TPP is the main coenzyme form of vitamin B1 and participates in two important reactions in the body, namely α- Oxidative decarboxylation of ketoacids and transketolase reaction via pentose phosphate pathway. The former is a key link in the biological oxidation process of mitochondria. Pyruvic acid derived from glucose, fatty acid, Branched-chain amino acid and α- Ketone Glutaric acid can enter the Citric acid cycle for complete oxidation only after Oxidative decarboxylation to produce acetyl CoA and succinyl CoA.      The latter is mainly carried out in the cytoplasm through transketolase, which can transfer α- The ketone group is transferred to ribose 5-phosphate to form Sedoheptulose and Glyceraldehyde 3-phosphate. This reaction is reversible. Although not an important pathway for glucose oxidation energy supply, it is an important source of pentose and NADPH required for nucleic acid synthesis and lipid and steroid synthesis. Due to the fact that acetyl CoA and succinyl CoA are key links in the decomposition and metabolism of thermogenic nutrients, as well as their synthesis and metabolism junctions, severe deficiency of vitamin B1 can cause widespread damage to the body.
In addition, vitamin B1 plays an important role in maintaining normal nerve and muscle function, especially myocardial function, as well as maintaining normal appetite, gastrointestinal peristalsis, and digestive secretion. In recent years, it has been confirmed that vitamin B1 belongs to a non coenzyme function, which may be related to TPP directly activating nerve cell chloride channels and controlling neural conduction initiation.


 
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