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Cilnidipine

Name: Cilnidipine

CAS No.: 132203-70-4

Appearance: light yellow powder

Molecular formula: ight yellow

Molecular Weight: 492.52

Melting point:97-99°C

PACKAGE:5KG/TIN


  • CAS No:

    132203-70-4
  • Packaging:

    5KGS/TIN
  • Payment:

    T/T
  • product origin:

    China
  • Appearance:

    light yellow powder
  • Product Details

Description:

Cilnidipine is a light yellow powder, easily soluble in acetone or ethyl acetate, slightly soluble in methanol or ethanol, and almost insoluble in water. As a lipophilic dihydropyridine calcium antagonist, it can bind to the dihydropyridine site of the L-type calcium channel on the membrane of vascular smooth muscle cells, inhibit the transmembrane influx of Ca2+through the L-type calcium channel, relax and dilate vascular smooth muscle, and have a hypotensive effect. It can also inhibit the release of norepinephrine from sympathetic nerve endings and sympathetic nerve activity by inhibiting the transmembrane influx of Ca2+through the N-type calcium channel on the membrane of sympathetic nerve cells.

Application

Cilnidipine have antioxidant effects, inhibits vascular smooth muscle cell proliferation, improves left ventricular diastolic and systolic function, improves left ventricular hypertrophy, and improves insulin resistance. It may improve endothelial dilation function, improve coronary blood flow, improve cerebral blood flow, improve arterial stiffness, reduce myocardial infarction area and the risk of reperfusion arrhythmia, and control angina attacks.

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